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Selenate as a Substitute for Sulfate in the Measurement of Extracellular Fluid Volume^1,5,

Washington, D. C.

ABSTRACT

A pilot study was performed to demonstrate the feasibility of measuring a functional E.C.F. volume as a selenate space with sodium selenate labeled with ⁷⁵Se. This volume of fluid closely approximated the established sulfate space. The facility with which ⁷⁵Se can be measured on whole blood warrants further studies with this nuclide as a tracer.

Single case studies on dogs demonstrate reproductibility of measurements and fluctuations observed in the volume of fluid measured as a selenate space under different experimental conditions.

FOOTNOTES

¹ Supported in part by Joseph L. and Ray L. Freund Foundation.

⁵ From the Anesthesiology Research Laboratory and the Surgical Research Division—George Hyman Memorial Research Foundation, Washington Hospital Center.

² Research Fellow in Surgery, Washington Hospital Center.

³ Resident in Surgery, Washington Hospital Center.

⁴ Manager Radiopharmaceutical Services, E. R. Squibb & Sons.