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Simultaneous Resin Uptake Studies of Labeled Thyroxine and Triiodothyronine in Thyroid Disease¹

Indianapolis, Indiana

ABSTRACT

The resin uptake of both ¹³¹I-labeled triiodothyronine and ¹³¹I-labeled thyroxine (T₃-RU, T₄-RU) were performed concomitantly in 107 normal subjects and patients with thyroidal and nonthyroidal disease. The results indicate definite superiority of the T₄-RU in the diagnosis of hyperthyroidism. The delineation of the hypothyroid state is less satisfactory by either test alone although T₃-RU results and T₄-RU results are equally reliable. The concomitant performance of both increases the diagnostic reliability. Changes in resin uptake values with age in normal adults, as reported by others, were not seen in this group. The value of the resin uptake in following therapy of thyroid disease is particularly helpful in the event of inorganic or organic iodide contamination.

FOOTNOTES

¹ From the Radioisotope Service, Veterans Administration Hospital, and the Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana.

² Postdoctoral Fellow, National Heart Institute, U.S. Public Health Service, Grant No. HTS-5461.

³ Associate Professor of Medicine, Indiana University School of Medicine, and Chief, Radioisotope Service, Veterans Administration Hospital, Indianapolis, Indiana.