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The Combined Use of Iodine-125 and Iodine-131 in Autoradiographic Studies of Nodular Goiter

Detroit, Michigan

ABSTRACT

The sevenfold difference in the half lives of ¹²⁵I and ¹³¹I permits the interpretation of autoradiographs prepared from tissue in which both are present. With proper selection of dosage, autoradiographs exposed from time zero can be made to reflect predominantly the distribution of ¹³¹I; those from time 32 days or longer, mainly the distribution of iodine-125. This technique has proved practical for the study of nodular goiters containing autonomous functioning tissue when one isotope is administered during stimulation by exogenous TSH.

The decay of one microcurie of ¹²⁵I is equivalent to 3–4 µC of ¹³¹I in blackening dental film, and is equivalent to at least ten µC in blackening AR 10 stripping film. With a given tissue mixture of these isotopes, the relative effect of ¹³¹I will be greater when using dental film, and that of ¹²⁵I greater when using stripping film.

FOOTNOTES

¹ Division of Endocrinology, Henry Ford Hospital, Detroit, Michigan.

² Edsel B. Ford Institute for Medical Research, Henry Ford Hospital.