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The Turnover of Magnesium in Control Subjects and in Patients With Idiopathic Cardiomyopathy and Congestive Heart Failure Studied With Magnesium-28¹

New Orleans, La.

ABSTRACT

Daily turnover of magnesium in control subjects and in patients with idiopathic cardiomyopathy and congestive heart failure was studied with ²⁸Mg of high specific activity, administered by both oral and intravenous routes under controlled metabolic conditions. Gastrointestinal absorption of magnesium varied from 53% to 93% of the daily intake. Of the absorbed magnesium less than seven per cent was excreted in the urine in the first 24 hours, and less than 10% in two to three days. More than 90% of the absorbed magnesium was excreted in the urine very slowly. The patients with congestive heart failure had even slower rates of excretion. The magnesium in the urine was derived largely from the magnesium pool of the body, the newly absorbed magnesium being responsible for less than 18% of the daily urinary excretion. Endogenous secretion of magnesium into the fluids of the gastrointestinal tract was negligible.

FOOTNOTES

¹ Aided by grants from the National Institute of Health, the Rowell A. Billups Fund for Research in Heart Disease and the Rudolph Matas Mermorial Fund for the Kate Prewitt Hess Laboratory.

² From the Department of Medicine of the Tulane University School of Medicine, Charity Hospital of Louisiana and U.S. Public Health Service Hospital in New Orleans. Doctor Yun is the Third Gillentine Fellow of the Tulane Department of Medicine and is from the National Defense Medical Center, Taipei, Taiwan, Republic of China.