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Polyploidization and Aberration of Human Chromosomes Induced in vitro and in vivo with Ionizing Radiations³

Ann Arbor, Michigan

ABSTRACT

1. The occurrence of polyploidy and endoreduplication is increased in leukocytes following irradiation in vitro and in vivo. The occurrence of structural chromosomal abnormalities is again documented.

2. The radiations of ¹³¹I, cobalt-60 and x-rays have similar qualitative effects as measured by leukocyte cultures.

3. Information as to how long chromosomal damage will persist after irradiation is not as yet available and in one individual who had received ¹³¹I therapy shortly before our studies, no evidence of damage was seen.

4. Recent literature on polyploidization of chromosomes is presented and discussed.

FOOTNOTES

³ Presented at the 12th Annual Meeting of the Society of Nuclear Medicine, Bal Harbour, Florida, June 17–19, 1965.

¹ Veterans Administration Hospital, Ann Arbor, Michigan.

² University of Michigan School of Dentistry, Ann Arbor, Michigan.

³ Presented at the 12th Annual Meeting of the Society of Nuclear Medicine, Bal Harbour, Florida, June 17–19, 1965.