HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Porath, M.B. Articles by Gross, J. Search for Related Content PubMed Articles by Porath, M.B. Articles by Gross, J.

A Comparison of Iodine-125 and Iodine-131 as Tracers in the Diagnosis of Thyroid Disease. I. Physical Aspects^1,3,

Jerusalem, Israel

ABSTRACT

The Physical aspects of the use of ¹²⁵I for thyroid diagnosis have been studied.

1. It has been shown that for in vitro studies (urine and plasma) the effect of density on assay is negligible.

2. Using a 32.5 ml water standard and a five-inch, Lucite neck phantom, thyroid uptakes may be measured with an accuracy of ± 10% for thyroids in the 20 to 55 gm weight range, and ± 20% for 15 to 75 gm range.

3. The scanning resolution is improved by 20% for ¹²⁵I in comparison with iodine-131.

4. The possibility of estimating the depths of sources is indicated.

5. Iodine-125 and ¹³¹I easily may be used for double-tracer techniques.

6. The tracer dose of ¹²⁵I may be reduced by a factor of six, compared to ¹³¹I, without altering counting statistics.

7. For thyroid studies, the radiation dose to the thyroid may be reduced by a factor of ten.

FOOTNOTES

¹ This work was supported in part by a contract to J. G. from the International Atomic Energy Agency—and by grants from the Jack Schenkar Memorial Club, Covington, Kentucky, and the Rose Soibel Fimoff Memorial Club, Chicago, Illinois.

³ The Medical Physics Section, the Department of Oncology, and The Department of Experimental Medicine and Cancer Research, The Hebrew University Hadassah Medical School, Jerusalem, Israel.

² Present address: Medical Physics Section, Radioisotope Service, Hines VA Hospital Hines, Ill.