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Excretion of Sodium-24 and Barium-82 in Cystic Fibrosis¹

Athens, Greece

ABSTRACT

For the study of Cl and Na metabolism in C.F. patients, ²⁴Na and ⁸²Br was utilized in 13 patients and 15 controls. The ratio of the sweat to plasma counts of the isotope is approximately one in C.F. patients. Whereas, in controls it is 0.25. By this technique, two patients with a probable diagnosis of cystic fibrosis, which was made on both clinical and chemical grounds, were excluded from the C.F. group, and this impression was confirmed by their follow up and the subsequent clinical picture.

An attempt was made to correlate the excretion of ²⁴Na and ⁸²Br in the sweat with their excretion in the urine. In spite of an increased excretion of both isotopes in the sweat, their urinary elimination was essentially normal. No change was found in the extracellular fluid volume as determined by ⁸²Br in C.F. patients.

FOOTNOTES

¹ This study was supported by grant from the National Cystic Fibrosis Research Foundation, New York, U.S.A., from the Research Laboratory of the Pediatric Clinic of Athens University, and the Radioisotope Laboratory of St. Savas Hospital, Athens, Greece, and presented at the IV Middle East and Mediterranian Pediatric Congress, Athens, September, 1964.

² Pediatric Clinic of Athens U. Medical School, St. Sophie's Children's Hospital, Athens, Greece.