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Coronary Artery Bed Photoscanning Using Radioiodine Albumin Macroaggregates (RAMA)³

Chicago, Illinois

ABSTRACT

Following the injection of radioiodinated albumin macroaggregates into the coronary artery system, radioisotope photoscanning demonstrated artificially created myocardial infarcts in mongrel dogs. There was no demonstrable myocardial damage with the albumin dose used (0.05 mg). The toxic level of the albumin injection into the coronary artery system in dogs was not determined at this time.

This technique is satisfactory for investigating the integrity of the coronary arteriolar-capillary bed without interference from contiguous organ uptake.

This procedure should not be used in humans until extensive toxicity studies are completed to establish the safety limits of the injected macroaggregated albumin. Even then, one must proceed with caution if considering coronary injection in a patient with suspected myocardial infarct.

FOOTNOTES

³ Supported in part by grants from U.S. Public Health Service General Research Grant No. # 1-SO1-FR-05070-01 and the James Picker Foundation on recommendation of the committee on Radiology, National Academy of Science-National Research Council.

¹ From the Departments of Radiology and Medicine, Northwestern University Medical School, Chicago, Illinois, U.S.A.

² Nuclear Medicine Laboratory (JLQ), Heart Station (MS & PK), Chicago Wesley Memorial Hospital, Chicago, Illinois.