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The Journal of Nuclear Medicine Vol. 7 No. 12 928-934
© 1966 by Society of Nuclear Medicine
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In Vivo Reticulocyte Radioiron Assimilation

R. M. Donati1, M. A. Warnecke1 and N. I. Gallagher1

St. Louis, Missouri

ABSTRACT

An in vivo technique for the study of reticulocytes is presented. The capacity of transfused reticulocytes to assimilate radioiron in vivo was studied. The reticulocyte incorporates iron in vivo which does not necessarily have to traverse the marrow compartment in order to be incorporated. Coincident with reticulocyte iron incorporation the serum iron levels diminish, and the T 1/2 plasma clearance rate shortens.

FOOTNOTES

1 From the Radioisotope Laboratory, St. Louis Veterans Administration Hospital and the Department of Internal Medicine, St. Louis University School of Medicine, St. Louis, Missouri.






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Copyright © 1966 by the Society of Nuclear Medicine.