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Studies with Iodine-131-Labeled Antibody to Human Fibrinogen for Diagnosis and Therapy of Tumors

Denver, Colorado

ABSTRACT

Fifty patients with neoplasms were injected intravenously with purified and ¹³¹I-labeled rabbit antibodies to human fibrinogen and were evaluated with scintiscanning for diagnostic reliability. Fifty-six per cent of all tumors showed positive scans and a much higher percentage was obtained in scans of patients with metastases to the brian.

Using Beck's formula or head phantoms, in vivo concentration of ¹³¹I in the lesions was calculated and from these values estimations were made for 10 patients of the ß radiation dose that would be delivered to the tumor if 160 mC of ¹³¹I antifibrinogen were given. These ranged from 123 to 2900 rad. Whole body radiation (ß and ) was less than 200 rad. Reports are presented for two patients who received therapeutic trials, one of whom showed a regression of the lesion.

FOOTNOTES

¹ Argonne Cancer Research Hospital, Chicago, Illinois, operated by the University of Chicago for the U. S. Atomic Energy Commission.

² Department of Radiation Biology and Biophysics, University of Rocheaster School of Medicine and Dentistry, Rochester, New York. This paper is based on work performed under contract with the U. S. Atomic Energy Commission at the University of Rochester Atomic Energy Project.

³ Present address: Department of Surgery, University of Colorado Medical Center, Denver, Colorado.