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Radiopharmacology of a Simplified Technetium-99m-Colloid Preparation for Photoscanning¹

Seattle, Washington

ABSTRACT

Using a modification of a method suggested by Patton, ^99mTc-sulfur colloid can be rapidly produced by the reaction of thiosulfate with pertechnetate and perrhenate (ReO₄^–) carrier. The factors influencing the rate of reaction, ^99mTc-colloid yield and resultant colloidal particle size are presented.

The colloid can be stabilized with Dextran and, for daily use, aliquots of the reactants can be stored in a pre-mixed sterile from. Using such a "colloid kit" ^99mTc-colloid of 400 mu size can be routinely prepared in less than five minutes with 98% yield. The preparation is very suitable for photoscanning organs of the RES in man.

FOOTNOTES

¹ Supported in part by NIH Grant T1 AM 5402

² Fellow in Nuclear Medicine, Division of Nuclear Medicine, Depts. of Medicine and Radiology.

³ Associate Professor of Medicine and Radiology