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Low Radioiodine Uptake and High Serum PBI Levels from Hemorrhage into Thyroid Adenoma¹

New Orleans, Louisiana

ABSTRACT

After hemorrhagic degeneration of a large follicular adenoma of the thyroid, a patient's serum PBI level was more than twice the normal value. The 24-hour radioiodine uptake was less than five per cent of the administered dose of 100 µC of iodine-131. High-contrast photoscanning over the thyroid confirmed the low ¹³¹I uptake, and showed almost no ¹³¹I in the region of the adenoma. The high serum PBI levels were attributed to the passage of preformed hormone and hormonally-active iodinated amino acids from injured follicles into the circulation. The low ¹³¹I uptake was attributed to depressed secretion of thyroid stimulating hormone.

FOOTNOTES

¹ The Department of Medicine, The Touro Infirmary, New Orleans, Louisiana.

² Assistant Professor of Clinical Medicine, Tulane University School of Medicine, New Orleans, Louisiana, Clinician, Board of Health, City of New Orleans, Louisiana.

³ Present address: 3600 Prytania Street, New Orleans, Louisiana 70115.