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Correlation of Brain Scan Image and Area Counting After Scanning With Tumor Pathology^2,3

Ann Arbor, Michigan

ABSTRACT

One hundred and two brain scans with histologically verified brain tumors were studied in an attempt to correlate brain scans and area counting findings with tumor pathology. The following trends were noted;

1. Meningiomas commonly show sharply demarcated, round concentrations with moderately high differential uptake ratios. They are frequently large and localized in the parasagittal, parasylvian, sphenoid ridge and olfactory groove regions.

2. Astrocytomas usually present as small, round concentrations with frequent localization in the posterior fossa and low differential uptake ratios. The distribution in the cerebrum is usually wide.

3. Glioblastomas are frequently present as large, irregular isotope concentrations with high differential uptake ratios. Most deepseated tumors seen on brain scans are glioblastomas.

4. Metastatic carcinomas appear to be small and round with low differential uptake ratios. They are frequently found in occipital, posterior parietal, and posterior temporal regions. They are the most common cause of more than one positive image on a brain scan.

5. The most common types of posterior fossa tumors seen on brain scans are cerebellar astrocytomas, metastatic carcinomas, acoustic neurinomas and ependymomas. Accuracy of detecting these tumors by scans is approximately 70 percent.

FOOTNOTES

² This work was supported in part by the Nuclear Medicine Research Fund.

³ Presented to the Twelfth Annual Meeting of the Society of Nuclear Medicine, Bal Harbour, Florida, June 1965.

¹ Departments of Radiology and Medicine (Nuclear Medicine), University of Michigan Medical School, Ann Arbor, Michigan.