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The Journal of Nuclear Medicine Vol. 6 No. 9 651-666
© 1965 by Society of Nuclear Medicine
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The Use of Positron Emitter in the Determination of Coronary Blood Flow in Man

Alberto Cohem, M.D., Edward J. Zaleski, M.D., Eide-Dittmar Luebs, M.D. and Richard J. Bing, M.D.1,2,

Detroit, Michigan

ABSTRACT

The concepts underlying a coincidence counting method for the measurement of coronary blood flow using 84Rb, a positron emitter, is described. Coronary blood flow is calculated by the logarithmic extrapolation of the myocardial clearance values of 84Rb to zero time. At this time, the myocardial extraction ratio is unity. The accuracy of the method has been established in experiments on the isolated dog heart. All calculations are objectively performed by a digital computer.

The resting coronary blood flows in individuals above and below the age of 40 and in males and females were not statistically different. In addition, there were no significant differences in the resting coronary blood flows in patients with and without coronary artery disease.

The observation that sublingual administration of nitroglycerin increases the coronary blood flow in individuals without coronary artery disease while failing to increase it in patients with coronary artery disease has been used as a diagnostic test in the recognition of coronary artery disease.

FOOTNOTES

1 From the Department of Medicine, Wayne State University School of Medicine, Detroit, Michigan, and Harper Hospital, Detroit, Michigan.

2 Work supported by USPHS Research Grant No. HE-05043, The John A. Hartford Foundation, The Council for Tobacco Research—USA, and The A.M.A. Education and Research Foundation.






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Copyright © 1965 by the Society of Nuclear Medicine.