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Transfer Rates of Gamma Globulin Between Cerebrospinal Fluid and Blood Plasma (Results Obtained on A Series of Multiple Sclerosis Patients)

Winston-Salem, N.C., Brooklyn, N.Y., Los Angeles, Cal. and Upton, N.Y.

ABSTRACT

¹³¹I gamma globulin was injected both intravenously and intrathecally into patients with multiple sclerosis with subsequent sampling of blood and cerebrospinal fluid. Specific activity versus time curves were constructed from the data obtained from these samples. The transfer rate of gamma globulin from the cerebrospinal fluid to the blood plasma was 11.6 times as rapid as from the blood plasma to the cerebrospinal fluid compartment. The average time a molecule of gamma globulin spent in the cerebrospinal fluid compartment was 17.3 hours; whereas, in the blood plasma compartment it was 72.4 hours. The gamma globulin in the cerebrospinal fluid compartment was found to be replaced 4.2 times as fast as it was in the blood plasma compartment.

FOOTNOTES

¹ From the Department of Pathology, Bowman Gray School of Medicine of Wake Forest College, Winston-Salem, North Carolina, the Department of Medicine, Jewish Chronic Disease Hospital, Brooklyn, New York, the Departments of Surgery and Physiology, University of California School of Medicine, Los Angeles, California, and the Medical Department, Brookhaven National Laboratory, Upton, New York.

² This research was supported by the National Multiple Sclerosis Society, Grant No. 339, and by the United States Atomic Energy Commission.

³ Presented at the Twelfth Annual Meeting of the Society of Nuclear Medicine, Bal Harbour, Florida, June 19, 1965.

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