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Influence of Dimethyl Sulfoxide on the Radiation Sensitivity of Catalase

Little Rock, Arkansas

ABSTRACT

The change in radiosensitivity of catalase by dimethyl sulfoxide was investigated spectrophotometrically. The enzyme-DMSO mixtures were irradiated with different doses of x-rays (2.25 x 10⁶ R) at room temperature. The results obtained show that DMSO provides a good radioprotective effect. This protective effect might be explained by a complex formation between Fe³⁺, the active site in catalase, and the protective compound. The existence of such a complex has been shown by electron spin resonance and optical absorption studies. Both the variation in line width (ESR spectra) and the optical "red shift" obtained suggest a change in crystal-field energy levels by spin-orbit mechanisms.

FOOTNOTES

¹ Departments of Physiology and Medicine, University of Arkansas Medical Center and VA Southern Research Support Center, Little Rock, Arkansas.

² This work was supported in part by USPHS Research Grant No. RHOO-197.