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A Simple Method of Producing ¹⁸F Fluoride for the Study of Bone Disease¹

Washington, D.C.

ABSTRACT

1. A simple method for the production of sterile, pyrogen free, carrier free ¹⁸F fluoride is described. Under the conditions of production, specific activities of 0.9 µC per gram 11.2 per cent ¹⁸O enriched water resulted.

2. A small amount of ²⁴Na was also present and methods for preventing the formation of this impurity are suggested. Its presence did not interfere with the use of the ¹⁸F fluoride.

3. Intravenously administered ¹⁸F fluoride is rapidly cleared from the blood. By four hours, 44 per cent of the administered dose appears in the urine; this represents almost the total urinary excretion of isotope. It is believed that nearly all the unexcreted fluoride is bound to bone.

4. The possible applications of ¹⁸F fluoride in clinical medicine are discussed.

FOOTNOTES

¹ From the Division of Nuclear Medicine, Walter Reed Army Institute of Research. Washington, D. C.

² Present address: William Beaumont Army Hospital, El Paso, Texas.