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Simultaneous Red Cell Mass and Plasma Volume Determinations Using ⁵¹Cr Tagged Red Cells and ¹²⁵I Labeled Albumin¹

Oklahoma City, Oklahoma

ABSTRACT

The simultaneous measurement of red cell mass and plasma volume is the best way to study both blood compartments under the same physiological conditions. ¹³¹I and ⁵¹Cr are difficult tracers to use because of their overlapping energy spectra.

We have successfully used ¹²⁵I labeled albumin and ⁵¹Cr labeled red cells as tracers. A method for this measurement is presented along with results in 10 normal subjects and 41 patients.

FOOTNOTES

¹ This study was financed by an American Cancer Society Institutional Grant.

² Present Address: Department of Physics, The University of Texas M. D. Anderson Hospital and Tumor Institute, Texas Medical Center, Houston, Texas.

³ Division of Radiation Therapy and Isotopes, University of Oklahoma Medical Center, Oklahoma City, Oklahoma.

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