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The Relative Dosage Required of Total Body X-Ray Vs Intravenous ³²P for Equal Effectiveness Against Leukemic Cells of the Lymphocytic Series or Granulocytic Series in Chromic Leukemia^1,2,

Portland, Oregon

ABSTRACT

Data is presented which indicates that when comparisons are made at equal time intervals after the first dose, 1 mc of ³²P given intravenously is equivalent in effect to 15 r of total-body x-ray irradiation, as herein defined, in its effect on the leukemic cells of the lymphocytic or the granulocytic series in chronic leukemia. With this ratio, clinical therapeutic effects were equal, as well as effects on the total cell population of the involved cell series. For the effects measured there is a definite threshold below which, in each patient, leukocyte counts and spleen and lymph node size are not reduced.

True radiation sensitivity of cell populations may differ greatly in different individuals and may change suddenly, either up or down, in the same individual at different times.

FOOTNOTES

¹ Presented in part before the Eleventh Annual Meeting of the Society of Nuclear Medicine, Berkeley, California, June 19, 1964.

² This work was supported in part by grants from the U. S. Atomic Energy Commission, Contract AT(45-1)-581; the U. S. Public Health Service, National Cancer Institute, Grant CA-6109; and the Medical Research Foundation of Oregon.

³ From the Division of Experimental Medicine, University of Oregon Medical School, Portland, Oregon 97201.