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The Renal Clearance of ¹³¹I Labeled Meglumine Diatrizoate (Renografin) in Man¹

Buffalo, New York

ABSTRACT

The simultaneous renal clearances of tracer amounts of Renografin ¹³¹I and inulin were determined for both kidneys in eleven, and for each kidney, in four human subjects. Statistical analysis revealed no significant difference between the clearances of Renografin ¹³¹I and inulin performed simultaneously. When the plasma concentration of Renografin was elevated by large doses of stable Renografin in two subjects, the clearances of inulin and Renografin ¹³¹I were similar. Renografin ¹³¹I can be substituted for inulin as a measure of glomerular filtration rate in man, and is of particular value in the performance of split function studies.

FOOTNOTES

¹ Supported by U.S.P.H.S. General Research Support Grant No. 1-301-SR-05400-01, the Junior Board of Buffalo General Hospital, United Health Foundation of Western New York, Grant No. G-64-BGH-1, Buswell Fellowship, and United Health Foundation of Western New York Grant No. S-64-UB-5.

² From the Departments of Urology and Internal Medicine, Buffalo General Hospital, Buffalo, New York.