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London, England
ABSTRACT
A method of calculating the minimum tumour size detectable with a given isotope and counting system is presented. An experimental measurement with a phantom is required and also the tumour and normal tissue concentrations of isotope must be known. These concentrations may often be found in terms of extracellular spaces. In this way, different isotopes, collimators and counting systems may be compared quantitatively. This may be a useful method of evaluating the many new isotopes which are being used. In this paper brain tumour localization is considered in detail, and it is found that a considerable gain may be obtained by using certain short lived isotopes. Owing to interference from radiation from the rest of the body, only positron emitters and low energy
emitters can be used for brain scanning. The minimum tumour size detectable and the optimum collimator resolution for brain scanning is discussed.
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