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The Journal of Nuclear Medicine Vol. 6 No. 11 838-843
© 1965 by Society of Nuclear Medicine
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Dextran Infusions and Extracellular Volume1,2,

Marcus A. Rothschild, Murray Oratz, Sidney S. Schreiber and Carole D. Evans

New York

ABSTRACT

1. The plasma volume and extracellular volume were determined in 15 control rabbits, 16 rabbits treated with dextran, and in five rabbits treated with dextran and cortisone. Albumin distribution was studied in 15 other rabbits treated identically.
2. Dextran infusions expanded the plasma volume but did not influence the interstitial space. Extravascular albumin was not lowered in the presence of a marked decrease in circulating albumin. The addition of cortisone resulted in an expanded extracellular and interstitial volume with a loss of extravascular albumin.

FOOTNOTES

1 This study was presented in part at the 11th Annual Meeting of the Society of Nuclear Medicine, Berkeley, California, June 1964.

2 This study was supported in part by USPHS Research Grant No. AM-02489.






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Copyright © 1965 by the Society of Nuclear Medicine.