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Retention of Radiocobalt by Hair, Bone and Vascular Tissue^1-2,

Rochester, New York
Wright-Patterson AFB, Ohio

ABSTRACT

Cobalt-58 retention studies were conducted over a 20-day period in young and old rats of both sexes. The data show that the uptake of the radioisotope was relatively high in aorta, kidney an liver; relatively low in blood, femur, and hair; and age-dependent only in aortic tissue. These differences in retention of radiocobalt have been interpreted as being related to the distribution and elemental composition of the structural proteins. The results suggest that elastin retinas more cobalt-58 than collagen or keratin. In agreement with this, the stable Co content has been found to be measurable only in elastin. The effects of age are shown by the enhanced uptake of cobalt-58 by aortic tissue of old rats. This finding correlates with previous evidence indicating an increased metal content and a change in amino acid composition of aortic tissue with increased age.

FOOTNOTES

¹ From the Department of Radiology, School of Medicine and Dentistry, University of Rochester, Rochester, New York, and USAF Hospital, Wright-Patterson AFB, Ohio.

² Aided in part by grant RH 00042, Division of Radiological Health, Bureau of State Services, U. S. Public Health Service, and by a grant from the Air Force Office of Scientific Research, Office of Aerospace Research, United States air Force. The contents of the paper reflect the authors' personal view and are not to be construed as a statement of official Air Force Policy. The experiments were conducted according to the "Rules Regarding Animal Care" as established by The American Medical Association.

³ School of Medicine and Dentistry, University of Rochester, Rochester, New York.

⁴ Present address: Department of Surgery, Albert Einstein College of Medicine, Yeshiva University, New York, New York.

⁵ USAF Hospital, Wright-Patterson AFB, Ohio.