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A Continuous Monitored Dialysis-Perfusion System for Biologic Application^1,2,

Hines, Illinois

ABSTRACT

A physical system is described which allows the monitoring of unidirectional diffusion of a radioisotope from a dialysis cell, this unidirectionality is verified. In addition, the characteristics of the elution curve for ²²Na from the dialysis cell are described, as is the reproducibility of the curve employing the same membrane, with serial changes of ²²Na and with changes of membrance. Applicability of the system is discussed, including the kinetics permitting the quantitation in terms of interaction constants of permeable labeled substances with nonlabeled substances.

FOOTNOTES

¹ From the Radioisotope Service, Veterans Administration Hospital, Hines, Illinois; University of Illinois College of Medicine; and Stritch School of Medicine, Loyola University, Chicago, Illinois.

² This work was supported in part by National Institute of Health Grant AM-6847.