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The Journal of Nuclear Medicine Vol. 6 No. 11 780-791
© 1965 by Society of Nuclear Medicine
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Manganese and Copper Levels in Human Urine1,2,3,

Eugene L. Kanabrocki, Lawrence F. Case, Theodore Fields, Leonard Graham, Edwin B. Miller, Y. T. Oester and E. Kaplan

Hines, Illinois

ABSTRACT

Four consecutive day urine collections were made by each of 16 apparently healthy male subjects ranging in age from five to 47 years. These urines were analyzed by a neutron activation technique for nondialyzable Mn and Cu. Average concentrations obtained were 0.8 ± 0.3 µg Mn per day, and 46.0 ± 9.7 µg Cu per day.

Total Cu concentration, 50.4 ± 11.1 µg per day, was obtained by chemical analysis of these same urines.

Similarity between the mean levels for total and non-dialyzable Cu suggest that the urine excreted Cu in normal subjects is present in a bound form.

Forty-five daily urines were also obtained from 14 hospitalized adult male subjects and were analyzed for non-dialyzable levels of Mn and Cu. Manganese appears to be elevated in patients with myocardial infarction, cirrhosis of the liver, obesity (starvation diet), and schizaphrenia. Copper appears to be elevated in patients with myocardial infarction and in Wilson's disease.

FOOTNOTES

1 Partially supported by U.S. Department of Health, Education and Welfare, National Institute of Health Grant No. RG9045.

2 From the Radioisotope Research Service, Veterans Administration Hospital, Hines, Illinois, and Stritch School of Medicine, Loyola University, Chicago.

3 Presented at the 11th Annual Meeting of the Society of Nuclear Medicine, Berkeley, California, June 20, 1964.






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Copyright © 1965 by the Society of Nuclear Medicine.