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Persisting Clone of Cells With an Abnormal Chromosome in a Woman Previously Irradiated

Bethesda, Maryland

ABSTRACT

Chromosome studies performed on the mother who gave birth to a dystrophic and malformed child showed two types of abnormality. The first abnormality consisted of a clone of cells characterized by frequent breaks in the same general region of long arms in the presumed chromosome No. 9. Since this was observed in the repeated blood cultures but not in the skin culture, the clone is probably confined to the blood forming tissue. The second abnormality consisted of a moderately increased rate of chromosome-type aberrations occurring at random in all chromosomes. This woman received 1550 rads to the skin for treatment of eczematous dermatitis during the preceding 16 years, resulting in an estimated dose of 242 rads to portions of the bone marrow and lymph nodes. The type of random chromosome abnormality observed in her blood cultures has been reported previously to be associated with exposure to radiation. The aberrant cell clone may also have been induced by the same etiological factor.

FOOTNOTES

¹ Section on Child Neurology, SN, NINDB, National Institutes of Health, Bethesda, Maryland.

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