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Radioactive Iodine Treatment of Intractable Angina Pectoris

Chicago, Illinois

ABSTRACT

The effectiveness of ¹³¹I ablative therapy in a series of 80 patients with intractable angina pectoris is evaluated. Meaningful follow-up information was available in 48 patients who constituted the actual study group. Thirty of 39 patients (76 per cent) rendered hypothyroid showed significant improvement. However, six of nine patients remaining euthyroid also showed significant improvement.

This study also affords a comparison of the single and multiple dose forms of ¹³¹I therapy and, aside from an apparent decrease in the incidence of radiation thyroiditis, no significant difference between these two forms of ¹³¹I therapy was noted. No attempt was made to compare the evolution of the anginal syndrome in a similar control group, and no allowance was made for the possible contributory role of other forms of medical therapy after the administration of radioactive iodine. No estimate of the effect of ¹³¹I therapy on survival was attempted.

Although the results achieved in this study are entirely comparable to those previously reported, the virtually identical improvement rate obtained in the smaller group of patients remaining euthyroid would seem to preclude meaningful assessment of the efficacy of this form of therapy.

FOOTNOTES

¹ From the Radioisotope Laboratory, Department of Metabolism and Endocrinology, Division of Medicine, Michael Reese Hospital and Medical Center, Chicago, Illinois.