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First published online January 15, 2010, 10.2967/jnumed.109.068734
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Journal of Nuclear Medicine Vol. 51 No. 2 288-292
© 2010 by Society of Nuclear Medicine
doi: 10.2967/jnumed.109.068734

Basic Science Investigation

Fetal Dose Estimates for 18F-Fluoro-L-Thymidine Using a Pregnant Monkey Model

Rachel M. Bartlett, Robert J. Nickles, Todd E. Barnhart, Bradley T. Christian, James E. Holden and Onofre T. DeJesus

Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin–Madison, Madison, Wisconsin

Correspondence: For correspondence or reprints contact: Onofre T. DeJesus, School of Medicine and Public Health, University of Wisconsin–Madison, B1316, Wisconsin Institute of Medical Research (WIMR), 1111 Highland Ave., Madison, WI 53705. E-mail: odejesus{at}wisc.edu

Estimating the radiation dose received by the fetus from nuclear medicine procedures is important because of the greater sensitivity of rapidly developing fetal tissues to ionizing radiation. 18F-fluoro-L-thymidine (FLT) uptake is related to cellular proliferation and is currently used to monitor tumor progression and response to therapy. This study was undertaken to estimate—on the basis of biodistribution data obtained by PET/CT in pregnant rhesus monkeys—radiation absorbed dose to a human fetus administered 18F-FLT. Methods: Three pregnant rhesus macaques (gestational age, 113 ± 8 d) were administered 18F-FLT and imaged for 2 h on a PET/CT scanner. Time–activity curves for maternal and fetal organs were generated in anatomic regions of interest identified via CT. Doses were estimated using OLINDA/EXM and the 6-mo-pregnant human model. Results: The extrapolated whole-body maternal dose obtained, 11.4 µGy/MBq, is similar to the previously reported adult female dose of 15.6 µGy/MBq. The estimated total-body dose to a human fetus is 24 µGy/MBq. Significant long-term 18F-FLT accumulation in fetal liver resulted in a fetal liver dose of 53 µGy/MBq. Conclusion: The fetal dose estimate in a 6-mo-pregnant human using 18F-FLT is slightly greater than that reported for 18F-FDG. 18F-FLT trapping in the fetal liver should be considered in the risk–benefit analysis of 18F-FLT PET examination in pregnant patients.

Key Words: 18F-fluoro-L-thymidine (FLT) • fetus • dosimetry

COPYRIGHT © 2010 by the Society of Nuclear Medicine, Inc.


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