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Journal of Nuclear Medicine Vol. 51 No. 2 282-287
© 2010 by Society of Nuclear Medicine
doi: 10.2967/jnumed.109.065946

Basic Science Investigation

Design and Optimization of Coin-Shaped Microreactor Chips for PET Radiopharmaceutical Synthesis

Arkadij M. Elizarov1,2, R. Michael van Dam2, Young Shik Shin2, Hartmuth C. Kolb1, Henry C. Padgett1, David Stout3, Jenny Shu3, Jiang Huang4, Antoine Daridon4 and James R. Heath2

1 Siemens Molecular Imaging, Biomarker Research, Culver City, California; 2 Nanosystems Biology Cancer Center, California Institute of Technology, Pasadena, California; 3 Department of Molecular and Medical Pharmacology, University of California, Los Angeles, California; and 4 Fluidigm Corporation, South San Francisco, California

Correspondence: For correspondence or reprints contact: Arkadij M. Elizarov, Siemens Healthcare, 6100 Bristol Pkwy., Culver City, CA 90230. E-mail: arkadij.elizarov{at}siemens.com

An integrated elastomeric microfluidic device, with a footprint the size of a postage stamp, has been designed and optimized for multistep radiosynthesis of PET tracers. Methods: The unique architecture of the device is centered around a 5-µL coin-shaped reactor, which yields reaction efficiency and speed from a combination of high reagent concentration, pressurized reactions, and rapid heat and mass transfer. Its novel features facilitate mixing, solvent exchange, and product collection. New mixing mechanisms assisted by vacuum, pressure, and chemical reactions are exploited. Results: The architecture of the reported reactor is the first that has allowed batch-mode microfluidic devices to produce radiopharmaceuticals of sufficient quality and quantity to be validated by in vivo imaging. Conclusion: The reactor has the potential to produce multiple human doses of 18F-FDG; the most impact, however, is expected in the synthesis of PET radiopharmaceuticals that can be made only with low yields by currently available equipment.

Key Words: radiosynthesis • microfluidics • PET • 18F-FDG • instrumentation

Guest Editor: John Katzenellenbogen, University of Illinois

COPYRIGHT © 2010 by the Society of Nuclear Medicine, Inc.


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