JNM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH RSS TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     



First published online January 15, 2010, 10.2967/jnumed.109.068783
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
jnumed.109.068783v1
51/2/219    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in JNM
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Google Scholar
Right arrow Articles by Uda, T.
Right arrow Articles by Ohata, K.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Uda, T.
Right arrow Articles by Ohata, K.
Journal of Nuclear Medicine Vol. 51 No. 2 219-222
© 2010 by Society of Nuclear Medicine
doi: 10.2967/jnumed.109.068783

Clinical Investigation

Evaluation of the Accumulation of 11C-Methionine with Standardized Uptake Value in the Normal Brain

Takehiro Uda, Naohiro Tsuyuguchi, Yuzo Terakawa, Toshihiro Takami and Kenji Ohata

Department of Neurosurgery, Graduate School of Medicine, Osaka City University, Osaka, Japan

Correspondence: For correspondence or reprints contact: Takehiro Uda, Department of Neurosurgery, Graduate School of Medicine, Osaka City University, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan. E-mail: uda{at}med.osaka-cu.ac.jp

The aim of this study was to determine the normal L-[methyl-11C]-methionine (11C-methionine) uptake and the extent of variation using standardized uptake value (SUV). Methods: Five healthy volunteers and 58 adult patients with normal 11C-methionine uptake were included in the interindividual analysis and 22 patients in the intraindividual analysis. SUVs in different brain regions, age-associated changes, correlation between 2 correction methods (for body weight [w-SUV] or body surface area [s-SUV]), and intraindividual reproducibility were examined. Results: w-SUVs were statistically different between the brain regions. The frontal or parietal cortex showed lower coefficients of variation than did the cerebellum or brain stem. There was no significant age-associated change. w-SUVs showed lower coefficients of variation in interindividual analysis and lower symmetric percentage change in intraindividual reproducibility than did s-SUVs. Conclusion: SUVs in the normal brain show inter- and intraindividual variation, and our proposed normal w-SUVs represent an important reference value.

Key Words: 11C-methionine PET • normal accumulation • standardized uptake value

COPYRIGHT © 2010 by the Society of Nuclear Medicine, Inc.


Related articles in JNM:

This Month in JNM

JNM 2010 51: 11A-12A. [Full Text]  





HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH RSS TABLE OF CONTENTS
JOURNAL OF NUCLEAR MEDICINE TECHNOLOGY THE JOURNAL OF NUCLEAR MEDICINE
Copyright © 2010 by the Society of Nuclear Medicine.