HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH RSS TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) All Versions of this Article: jnumed.109.065532v1 51/1/46    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JNM Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Herzog, B. A. Articles by Kaufmann, P. A. PubMed PubMed Citation Articles by Herzog, B. A. Articles by Kaufmann, P. A.

Nuclear Myocardial Perfusion Imaging with a Cadmium-Zinc-Telluride Detector Technique: Optimized Protocol for Scan Time Reduction

¹ Cardiac Imaging, University Hospital Zurich, Zurich, Switzerland; ² GE Healthcare, Tirat Hacarmel, Israel; and ³ Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, Zurich, Switzerland

Correspondence: For correspondence or reprints contact: Philipp A. Kaufmann, Cardiac Imaging, University Hospital Zurich, Ramistrasse 100, CH-8091 Zurich, Switzerland. E-mail: pak{at}usz.ch

We aimed at establishing the optimal scan time for nuclear myocardial perfusion imaging (MPI) on an ultrafast cardiac -camera using a novel cadmium-zinc-telluride (CZT) solid-state detector technology. Methods: Twenty patients (17 male; BMI range, 21.7–35.5 kg/m²) underwent 1-d ^99mTc-tetrofosmin adenosine stress and rest MPI protocols, each with a 15-min acquisition on a standard dual-detector SPECT camera. All scans were immediately repeated on an ultrafast CZT camera over a 6-min acquisition time and reconstructed from list-mode raw data to obtain scan durations of 1 min, 2 min, etc., up to a maximum of 6 min. For each of the scan durations, the segmental tracer uptake value (percentage of maximum myocardial uptake) from the CZT camera was compared by intraclass correlation with standard SPECT camera data using a 20-segment model, and clinical agreement was assessed per coronary territory. Scan durations above which no further relevant improvement in uptake correlation was found were defined as minimal required scan times, for which Bland–Altman limits of agreement were calculated. Results: Minimal required scan times were 3 min for low dose (r = 0.81; P < 0.001; Bland–Altman, –11.4% to 12.2%) and 2 min for high dose (r = 0.80; P < 0.001; Bland–Altman, –7.6% to 12.9%), yielding a clinical agreement of 95% and 97%, respectively. Conclusion: We have established the minimal scan time for a CZT solid-state detector system, which allows 1-d stress/rest MPI with a substantially reduced acquisition time resulting in excellent agreement with regard to uptake and clinical findings, compared with MPI from a standard dual-head SPECT -camera.

Key Words: clinical cardiology • SPECT • cadmium-zinc-telluride detector • myocardial perfusion imaging • ultrafast

^* Contributed equally to this work.

COPYRIGHT © 2010 by the Society of Nuclear Medicine, Inc.

Related articles in JNM:

This Month in JNM

JNM 2010 51: 9A-10A. [Full Text]