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Radioisotopic Imaging of Neuroinflammation

CEA, I²BM, Service Hospitalier Frédéric Joliot, LIME, INSERM U803, Orsay, France

Correspondence: For correspondence or reprints contact: Bertrand Tavitian, Laboratoire d'Imagerie Moléculaire Expérimentale, INSERM U803, CEA-DSV-I²BM-Service Hospitalier Frédéric Joliot-LIME, 4 Place du Général Leclerc, 91400 Orsay, France. E-mail: bertrand.tavitian{at}cea.fr

ABSTRACT

Inflammatory responses are closely associated with many neurologic disorders and influence their outcome. In vivo imaging can document events accompanying neuroinflammation, such as changes in blood flow, vascular permeability, tightness of the blood-to-brain barrier, local metabolic activity, and expression of specific molecular targets. Here, we briefly review current methods for imaging neuroinflammation, with special emphasis on nuclear imaging techniques.

Key Words: neuroinflammation • microglia • blood-brain barrier • cell tracking • positron emission tomography • peripheral benzodiazepine receptor

FOOTNOTES

COPYRIGHT © 2010 by the Society of Nuclear Medicine, Inc.

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