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First published online July 17, 2009, 10.2967/jnumed.108.061341
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Journal of Nuclear Medicine Vol. 50 No. 8 1283-1287
© 2009 by Society of Nuclear Medicine
doi: 10.2967/jnumed.108.061341

Clinical Investigation

11C-Methionine PET of Acute Myocardial Infarction

Miyako Morooka1, Kazuo Kubota1, Hiromu Kadowaki2, Kimiteru Ito1, Osamu Okazaki2, Mitsuo Kashida2, Takuya Mitsumoto1, Ren Iwata3, Kuni Ohtomo4 and Michiaki Hiroe2

1 Division of Nuclear Medicine, Department of Radiology, International Medical Center of Japan, Tokyo, Japan; 2 Department of Cardiology, International Medical Center of Japan, Tokyo, Japan; 3 Department of Radiopharmaceutical Chemistry, Cyclotron Radioisotope Center, Tohoku University, Sendai, Miyagi, Japan; and 4 Department of Radiology, University of Tokyo, Tokyo, Japan

Correspondence: For correspondence or reprints contact: Kazuo Kubota, International Medical Center of Japan, 1-21-1 Toyama, Shinjuku-ku, Tokyo, 162-8655 Japan. E-mail: kkubota{at}imcj.hosp.go.jp or kkubota{at}cpost.plala.or.jp

Tissue uptake of L-[methyl-11C]-methionine (11C-methionine) has been used to monitor amino acid metabolism and protein synthesis. We examined whether 11C-methionine was retained in areas of myocardial infarction after successful reperfusion. Methods: Nine patients with infarction in the left anterior descendent region underwent percutaneous transluminal coronary artery intervention within 24 h and 201Tl SPECT, 18F-FDG PET, and 11C-methionine PET within 2 wk of infarction onset. The standardized uptake values of the infarcted area and of the normal area were measured. Results: The 11C-methionine images showed increased uptake in the infarcted area, whereas the 201Tl SPECT and 18F-FDG PET images showed decreased uptake. The highest accumulation of 11C-methionine in the infarcted area was observed during the early phase of AMI. Conclusion: 11C-methionine uptake is elevated in infarcted areas and may reflect the early acute phase of damage healing, that is, the initial process of remodeling.

Key Words: 11C-methionine • myocardial infarction • PET • 18F-FDG • remodeling

COPYRIGHT © 2009 by the Society of Nuclear Medicine, Inc.


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