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The Clinical Value of Myocardial Blood Flow Measurement^*

Medical Research Council, Clinical Sciences Centre and National Heart and Lung Institute, Imperial College, London, United Kingdom

Correspondence: For correspondence or reprints contact: Paolo G. Camici, Medical Research Council, Clinical Sciences Centre, Hammersmith Hospital, Du Cane Rd., London, W12 0NN United Kingdom. E-mail: paolo.camici{at}csc.mrc.ac.uk

PET provides robust and reproducible measurements of regional myocardial blood flow in milliliters per minute per gram of tissue, providing unique pathophysiologic and diagnostic information on the function of the coronary macro- and microcirculation. There is compelling evidence to suggest that in many instances abnormalities of global myocardial perfusion are demonstrated in individuals with either coronary risk factors for coronary artery disease or different myocardial diseases in the absence of angiographically demonstrable stenosis of the epicardial coronary arteries. In this context, measurement of myocardial blood flow gives unique diagnostic information regarding the function of the coronary microcirculation and provides a quantitative surrogate endpoint against which the efficacy of treatments can be established.

Key Words: noninvasive measurement • cardiovascular disease • myocardial blood flow

^* NOTE: FOR CE CREDIT, YOU CAN ACCESS THIS ACTIVITY THROUGH THE SNM WEB SITE (http://www.snm.org/ce_online) THROUGH JULY 2010.

Paolo G. Camici has indicated he is a consultant/advisor for GE Healthcare. No other potential conflict of interest relevant to this article was reported.

COPYRIGHT © 2009 by the Society of Nuclear Medicine, Inc.

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