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First published online June 12, 2009, 10.2967/jnumed.109.064055
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Journal of Nuclear Medicine Vol. 50 No. 7 1013-1016
© 2009 by Society of Nuclear Medicine
doi: 10.2967/jnumed.109.064055

Focus on Molecular Imaging

Nuclear Imaging of Cancer Cell Therapies

Vladimir Ponomarev

Department of Radiology, Memorial Sloan-Kettering Cancer Center

Correspondence: For correspondence or reprints contact: Vladimir Ponomarev, Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave., Z-2063 New York, NY 10021. E-mail: ponomarv{at}mskcc.org

ABSTRACT

A promising role of cellular therapies in cancer treatment is reflected by the constantly growing number of clinical trials with adoptively transferred cells. Direct and indirect cell labeling for the nuclear imaging of transferred cells has been proven reliable for imaging adoptive cellular therapies. Both methods show their advantages and limitations. Direct labeling is a relatively easy, inexpensive, and well-established methodology. Indirect labeling using a reporter gene imaging paradigm allows for reliable, stable, and harmless visualization of cellular trafficking, persistence, proliferation, and function at the target site. It is expected that new human-derived reporter genes will be rapidly translated into clinical applications that require repetitive imaging for the effective monitoring of various genetic and cellular therapies.

Key Words: molecular imaging • oncology • PET/CT • cell therapy • reporter gene

FOOTNOTES

COPYRIGHT © 2009 by the Society of Nuclear Medicine, Inc.


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Copyright © 2009 by the Society of Nuclear Medicine.