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First published online May 14, 2009, 10.2967/jnumed.109.062687
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Journal of Nuclear Medicine Vol. 50 No. 6 912-919
© 2009 by Society of Nuclear Medicine
doi: 10.2967/jnumed.109.062687

Basic Science Investigation

Uptake of 18F-Labeled 6-Fluoro-6-Deoxy-D-Glucose by Skeletal Muscle Is Responsive to Insulin Stimulation

Chandra Spring-Robinson1, Visvanathan Chandramouli2, William C. Schumann2, Peter F. Faulhaber3, Yanming Wang3,4, Chunying Wu3,4, Faramarz Ismail-Beigi2 and Raymond F. Muzic, Jr.1,3,4

1 Department of Biomedical Engineering, University Hospitals Case Medical Center, School of Medicine, Case Western Reserve University, Cleveland, Ohio; 2 Department of Medicine, University Hospitals Case Medical Center, School of Medicine, Case Western Reserve University, Cleveland, Ohio; 3 Department of Radiology, University Hospitals Case Medical Center, School of Medicine, Case Western Reserve University, Cleveland, Ohio; and 4 Case Center for Imaging Research, University Hospitals Case Medical Center, School of Medicine, Case Western Reserve University, Cleveland, Ohio

Correspondence: For correspondence or reprints contact: Raymond F. Muzic, Jr., Department of Radiology, University Hospitals Case Medical Center, 11100 Euclid Ave., Cleveland, OH 44106. E-mail: raymond.muzic{at}case.edu

We are developing a methodology for the noninvasive imaging of glucose transport in vivo with PET and 18F-labeled 6-fluoro-6-deoxy-D-glucose (18F-6FDG), a tracer that is transported but not phosphorylated. To validate the method, we evaluated the biodistribution of 18F-6FDG to test whether it is consistent with the known properties of glucose transport, particularly with regard to insulin stimulation of glucose transport. Methods: Under glucose clamp conditions, rats were imaged at the baseline and under conditions of hyperinsulinemia. Results: The images showed that the radioactivity concentration in skeletal muscle was higher in the presence of insulin than at the baseline. We also found evidence that the metabolism of 18F-6FDG was negligible in several tissues. Conclusion: 18F-6FDG is a valid tracer that can be used in in vivo transport studies. PET studies performed under glucose clamp conditions demonstrated that the uptake of nonphosphorylated glucose transport tracer 18F-6FDG is sensitive to insulin stimulation.

Key Words: glucose transport • radiopharmaceutical • PET • glucose clamp

COPYRIGHT © 2009 by the Society of Nuclear Medicine, Inc.


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