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First published online April 16, 2009, 10.2967/jnumed.108.058479
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Journal of Nuclear Medicine Vol. 50 No. 5 667-670
© 2009 by Society of Nuclear Medicine
doi: 10.2967/jnumed.108.058479

Focus on Molecular Imaging

Recent Advances in Small-Animal Cardiovascular Imaging

Benjamin M.W. Tsui and Dara L. Kraitchman

Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland

Correspondence: For correspondence or reprints contact: Benjamin M.W. Tsui, Johns Hopkins University School of Medicine, Russell H. Morgan Department of Radiology and Radiological Science, 601 N. Caroline St., Baltimore, MD 21287. E-mail: tsui{at}jhmi.edu

ABSTRACT

Because of the development of gene knockout and transgenic technologies, small animals, such as mice and rats, have become the most widely used animals for cardiovascular imaging studies. Imaging can provide a method to serially evaluate the effect of a particular genetic mutation or pharmacologic therapy (1). In addition, imaging can be used as a noninvasive screening tool for particular cardiovascular phenotypes. Outcome measures of therapeutic efficacy, such as ejection fraction, left ventricular mass, and ventricular volume, can be determined noninvasively as well. Furthermore, small-animal imaging can be used to develop and test new molecular imaging probes (2,3). However, the small size of the heart and rapid heart rate of murine models create special challenges for cardiovascular imaging.

Key Words: molecular imaging • MI • animal imaging • cardiovascular • small animal

FOOTNOTES

COPYRIGHT © 2009 by the Society of Nuclear Medicine, Inc.


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