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First published online February 17, 2009, 10.2967/jnumed.108.058693
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Journal of Nuclear Medicine Vol. 50 No. 3 397-400
© 2009 by Society of Nuclear Medicine
doi: 10.2967/jnumed.108.058693

Brief Communication

99mTc-HYNIC-TOC Scintigraphy Is Superior to 131I-MIBG Imaging in the Evaluation of Extraadrenal Pheochromocytoma

Libo Chen1, Fang Li1, Hongming Zhuang2, Hongli Jing1, Yanrong Du1 and Zhengpei Zeng3

1 Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China; 2 Department of Radiology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania; and 3 Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China

Correspondence: For correspondence or reprints contact: Fang Li, Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, No. 1, Shuaifuyuan, Wangfujing St., Dongcheng District, Beijing, 100730, P.R. China. E-mail: lifang5502{at}sohu.com

In this investigation, the efficacy of scintigraphy using 99mTc-labeled hydrazinonicotinyl-Tyr3-octreotide (HYNIC-TOC) in the evaluation of extraadrenal pheochromocytoma was assessed and compared with 131I-labeled metaiodobenzylguanidine (MIBG) imaging. Methods: Ninety-seven patients who were suspected of having pheochromocytoma but showed no definite adrenal abnormalities on CT were evaluated by both 99mTc-HYNIC-TOC scintigraphy and 131I-MIBG imaging. The results were compared with pathology findings or clinical follow-up. Results: Of 58 patients proven to be without pheochromocytoma, 99mTc-HYNIC-TOC and 131I-MIBG imaging excluded 56 and 58 patients, respectively, rendering a specificity of 96.6% for 99mTc-HYNIC-TOC imaging and 100% for 131I-MIBG imaging. In the evaluation of adrenal pheochromocytoma (14 patients), the sensitivity of 99mTc-HYNIC-TOC scintigraphy and 131I-MIBG imaging was 50% and 85.7%, respectively. However, in the evaluation of extraadrenal pheochromocytomas (25 patients), the sensitivity of 99mTc-HYNIC-TOC scintigraphy and 131I-MIBG imaging was 96.0% and 72.0%, respectively. Conclusion: 99mTc-HYNIC-TOC scintigraphy is more sensitive than 131I-MIBG imaging in the detection of extraadrenal pheochromocytomas.

Key Words: extraadrenal pheochromocytoma • 99mTc-hydrazinonicotinyl-tyr3-octreotide (HYNIC-TOC) • metaiodobenzylguanidine (MIBG)

COPYRIGHT © 2009 by the Society of Nuclear Medicine, Inc.


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