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First published online January 21, 2009, 10.2967/jnumed.108.053546
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Journal of Nuclear Medicine Vol. 50 No. 2 171-174
© 2009 by Society of Nuclear Medicine
doi: 10.2967/jnumed.108.053546

Focus on Molecular Imaging

Magnetic Tagging of Therapeutic Cells for MRI

Matthew D. Budde and Joseph A. Frank

National Institutes of Health Clinical Center
Bethesda, Maryland

Correspondence: For correspondence or reprints contact: Matthew D. Budde, Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Building 10, Room B1N256, 10 Center Dr., MSC 1074, Bethesda, MD 20892. E-mail: buddem{at}cc.nih.gov

ABSTRACT

Transplantation of stem cells or immune cells has shown promise for the treatment of several diseases. Monitoring magnetically labeled cells with MRI has furthered our understanding of cellular migration and the pathophysiology of diseases in experimental models. These studies should pave the way for guiding clinical trials using cell-based therapies. This review briefly describes the various methods used to label and track cells with MRI and the potential for such methods to translate to human applications.

Key Words: molecular imaging • MRI • magnetic cellular tagging • immune cells • stem cells

FOOTNOTES

COPYRIGHT © 2009 by the Society of Nuclear Medicine, Inc.


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Copyright © 2009 by the Society of Nuclear Medicine.