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First published online October 16, 2009, 10.2967/jnumed.108.054098
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Journal of Nuclear Medicine Vol. 50 No. 11 1820-1827
© 2009 by Society of Nuclear Medicine
doi: 10.2967/jnumed.108.054098

Continuing Education

18F-FDG Uptake in Lung, Breast, and Colon Cancers: Molecular Biology Correlates and Disease Characterization*

Hossein Jadvar1, Abass Alavi2 and Sanjiv S. Gambhir3

1 Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, California; 2 Department of Radiology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; and 3 Molecular Imaging Program at Stanford, Division of Nuclear Medicine, Department of Radiology, Stanford University, Stanford, California

Correspondence: For correspondence or reprints contact: Hossein Jadvar, 2250 Alcazar St., CSC 102 Keck School of Medicine, University of Southern California, Los Angeles, CA 90033. E-mail: jadvar{at}usc.edu

It is hoped that in the not too distant future, noninvasive imaging–based molecular interrogation and characterization of tumors can improve our fundamental understanding of the dynamic biologic behavior of cancer. For example, the new dimension of diagnostic information that is provided by 18F-FDG PET has led to improved clinical decision making and management changes in a substantial number of patients with cancer. In this context, the aim of this review is to bring together and summarize the current data on the correlation between the underlying molecular biology and the clinical observations of tumor 18F-FDG accumulation in 3 major human cancers: lung, breast, and colon.

Key Words: molecular biology • molecular imaging • oncology • PET • PET/CT • breast cancer • colon cancer • 18F-FDG • lung cancer

* NOTE: FOR CE CREDIT, YOU CAN ACCESS THIS ACTIVITY THROUGH THE SNM WEB SITE (http://www.snm.org/ce_online) THROUGH NOVEMBER 2010.

No potential conflict of interest relevant to this article was reported.

COPYRIGHT © 2009 by the Society of Nuclear Medicine, Inc.


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