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First published online October 16, 2009, 10.2967/jnumed.109.061846
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Journal of Nuclear Medicine Vol. 50 No. 11 1743-1746
© 2009 by Society of Nuclear Medicine
doi: 10.2967/jnumed.109.061846

Focus on Molecular Imaging

The Advantages of Nanoparticles for PET

Michael J. Welch1, Craig J. Hawker2 and Karen L. Wooley3,4

1 Departments of Radiology and Chemistry, Washington University, Saint Louis, Missouri; 2 Materials Research Laboratory, Department of Materials, and Department of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, California; 3 Departments of Chemistry and Radiology, Washington University, Saint Louis, Missouri; and 4 Department of Chemistry, Texas A&M University, College Station, Texas

Correspondence: For correspondence or reprints contact: Michael J. Welch, 510 S. Kingshighway Blvd., Departments of Radiology and Chemistry, Washington University, Saint Louis, MO 63110. E-mail: welchm{at}wustl.edu

ABSTRACT

Nanoparticles have an advantage for molecular imaging in that many functionalities can be added to the surface and interior of the particle. This brief review focuses on the design of nanomaterials that take advantage of PET. An evolutionary approach is presented, leading to the optimization of the nanoparticle composition and structure to achieve controlled in vivo circulation and tissue-selective targeting. Organic and inorganic nanostructures are included. Nanoprobes for PET of angiogenesis and cancer are highlighted.

Key Words: positron emission tomography • PET • nanoparticles • nanoscale structures • multifunctionality

FOOTNOTES

COPYRIGHT © 2009 by the Society of Nuclear Medicine, Inc.


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