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First published online September 16, 2009, 10.2967/jnumed.109.063925
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Journal of Nuclear Medicine Vol. 50 No. 10 1563-1566
© 2009 by Society of Nuclear Medicine
doi: 10.2967/jnumed.109.063925

Focus on Molecular Imaging

Multispectral Fluorescence Imaging

Lanlan Zhou and Wafik S. El-Deiry

Department of Bioengineering, University of Pennsylvania School of Engineering and Applied Science, Philadelphia, Pennsylvania; and Hematology-Oncology Division, Department of Medicine, Genetics, and Pharmacology, Abramson Comprehensive Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania

Correspondence: For correspondence or reprints contact: Wafik S. El-Deiry, 415 Curie Blvd., 437A, Clinical Research Building, Philadelphia, PA 19104. E-mail: wafik{at}mail.med.upenn.edu

ABSTRACT

Multispectral fluorescence imaging (MSFI) is a rapidly growing field with broad applications in both preclinical and clinical settings. Application of this novel technology in small-animal imaging and microscopy produces enhanced sensitivity and reliable quantification and resolves multiple simultaneous signals. MSFI flow cytometry can quantify multiple fluorescent parameters with morphologic or subcellular spatial details on millions of cells. MSFI has the potential to improve the accuracy of disease detection or differentiation and intrasurgical metastatic diagnosis, guide neurosurgeries, and monitor treatment response.

Key Words: multispectral fluorescence imaging • multiplexing • spectral unmixing • small-animal imaging • microscopy • flow cytometry

FOOTNOTES

COPYRIGHT © 2009 by the Society of Nuclear Medicine, Inc.


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