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Repeatability of Rest and Hyperemic Myocardial Blood Flow Measurements with ⁸²Rb Dynamic PET

¹ Department of Nuclear Medicine, Hokkaido University School of Medicine, Sapporo, Japan; ² Department of Molecular Imaging, Hokkaido University School of Medicine, Sapporo, Japan; ³ Department of Health Sciences, Hokkaido University School of Medicine, Sapporo, Japan; ⁴ Department of Cardiology, Hokkaido University School of Medicine, Sapporo, Japan; and ⁵ Cardiac PET Centre, University of Ottawa Heart Institute, Ottawa, Ontario, Canada

Correspondence: For correspondence or reprints contact: Keiichiro Yoshinaga, Department of Molecular Imaging, Hokkaido University School of Medicine, Kita15 Nishi7, Kita-Ku, Sapporo, Hokkaido, Japan 060-8638. E-mail: kyoshi{at}med.hokudai.ac.jp

The repeatability of rest and hyperemic myocardial blood flow (MBF) measurements using ⁸²Rb PET has not been evaluated. The aim of this study was to investigate the short-term repeatability of such measurements. Methods: Fifteen healthy volunteers underwent rest and pharmacologic stress ⁸²Rb PET, repeated 60 min apart. Results: There was no significant difference in repeated rest MBF (0.77 ± 0.25 vs. 0.82 ± 0.25 mL/min/g, P = 0.31; mean difference, 6.18% ± 12.22%) or repeated hyperemic MBF (3.35 ± 1.37 vs. 3.39 ± 1.37 mL/min/g, P = 0.81; mean difference, 1.17% ± 13.64%). The repeatability coefficients were 0.19 mL/min/g for rest MBF and 0.92 mL/min/g for hyperemia. Conclusion: MBF using ⁸²Rb is highly reproducible using a same-day short-term repeatability protocol. Serial MBF measurements with ⁸²Rb PET should have the ability to quantify the acute effects of therapeutic interventions on MBF.

Key Words: myocardial blood flow • pharmacologic stress • ⁸²Rb

COPYRIGHT © 2009 by the Society of Nuclear Medicine, Inc.

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