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A Fifteen Minute Test of the Rate of Thyroid Trapping of Radio-Iodine

Montreal

ABSTRACT

A simple 15 minutes thyroid function test is described. Continuous recording of radioiodine activity over the thyroid gland following intravenous injection is obtained, and the ratio of the count rate at 15 minutes to 5 minutes is estimated (R₁₅). The relationship of R₁₅ to the 24 hour uptake (T₂₄) is given by log R₁₅=0.292 log T₂₄–0.334, with a 0.87 coefficient of correlation. The value of R₁₅ is independent of the administered dose and insensitive to small changes in crystal-skin distance.

In 310 clinically evaluated patients the trapping rate index was found to be more sensitive in separating hyperthyroidism from euthyroidism than the conventional 24 hour uptake. The R₁₅ and T₂₄ were about equally efficient in distinguishing euthyroidism from hypothyroidism. TSH stimulation and T3 suppression can be readily determined and a greater insight into the pathophysiology of the thyroid disorder can be obtained by using this simple 15 minute test.

The author wishes to extend his appreciation to R. Beique, Ph.D. and D. Rotenberg, Ph.D. for their many helpful suggestions and statistical analysis. Thanks are due Hazel Male for patient preparation of the manuscript.

FOOTNOTES

¹ Department of Radiology, Montreal General Hospital, MONTREAL.