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Stimulation of Erythropoietin Production By Whole-Body Irradiation (Spleen Shielded)^1,2

Berkeley, California and Argentina

ABSTRACT

Increase in erythropoiesis in the spleen as a result of irradiating the remainder of the body has again been demonstrated. That the erythropoiesis in the shielded spleen can be abolished by hypertransfusion or administration of erythropoietin antibody and enhanced by administration of exogenous erythropoietin indicates that erythropoiesis in the shielded spleen is, like normal marrow, under erythropoietin control.

Since erythropoietin production is apparently increased in the absence of any known stimulant (anemia, hypoxia, or increased cobaltous ion concentration), it is suggested that irradiation may be a stimulus to the release of increased amounts of erythropoietin into the circulation via a mechanism not yet understood.

The results of this study indicate that increased erythropoiesis in the shielded spleen following irradiation results from a combination of doubling the erythropoietin production and increasing the sensistivity to erythropoietin.

FOOTNOTES

¹ From the Donner Laboratory of Medical Physics, Lawrence Radiation Laboratory, University of California, Berkeley, California, and the consejo Nacional de Investigaciones Cientificas y Tecnicas, Argentina.

² This work was supported in part by the United States Atomic Energy Commission.