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The Response of Disseminated Reticulum Cell Sarcoma to the Intravenous Injection of Colloidal Radioactive Gold¹

Rochester, New York and Oklahoma City

ABSTRACT

1. External radiation therapy remains the treatment of choice in localized reticulum cell sarcoma.

2. Intravenous colloidal radiogold may be a useful agent in lymphosarcomas with diffuse minute neoplastic involvement of the liver and spleen, and possibly minimal bone marrow involvement. It is essentially of no use in the treatment of involved lymph nodes or large masses.

Fig. 5. Case II (F.J.): Graphic illustration of response of peripheral blood to 50 mc. Au198 intravenously

3. Intravenous colloidal radiogold can produce bone marrow depression and thrombocytopenia which can lead to death. Patients so treated should be carefully followed with complete blood counts including platelet levels. A definite hypopasia of the bone marrow or anemia is a contraindication for the use of this agent.

4. No more than 50 mc. Au¹⁹⁸ intravenously should be used for treatment of this disease.

FOOTNOTES

¹ Presented at the Nuclear Society Meeting, Montreal, Canada, June, 1963.

² Chief, Division of Radiation Therapy and Radioisotopes, Strong Memorial Hospital, University of Rochester Medical Center, Rochester, New York.

³ Chief, Department of Radiation Therapy, University of Oklahoma Medical Center, Oklahoma City, Oklahoma.