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The Unexpected Incorporation of Unbound Iodide-131 Into the Non-Radioactive Hippuran Molecule^1,2,

Winston-Salem, North Carolina

ABSTRACT

Observations have been made that if the specific activity of a commercial preparation of iodine-131-labeled Hippuran containing contaminating free radioiodide is lowered by a factor of about 10,000 by dilution with a non-radioactive Hippuran solution, the per cent radioiodide contamination decreases upon standing over a period of time at room temperature in the dark. Furthermore, if sodium iodide-131 and non-radioactive Hippuran solutions are mixed, the per cent radioactivity due to iodide-131 rapidly decreases from the initial 100 per cent. An unknown radioactive compound is formed, presumably organic, which behaves chromatographically very similar to radio-Hippuran.

The addition of a solution of sodium diatrizoate to a sodium iodide-131 solution does not result in iodide-131 decrease. Cobalt-60 radiation and ultraviolet light do not appear to change the rate of iodide-131 decrease in solutions containing non-radioactive Hippuran and sodium iodide-131.

FOOTNOTES

¹ Department of Radiology of the Bowman Gray School of Medicine of West Forest College, Winston-Salem, North Carolina.

² Performed under Grant from U.S.P.H.S., N.I.H. 5418.