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A Preliminary Evaluation of F¹⁸-Labeled Tetrafluoroborate As A Scanning Agent For Intracranial Tumors¹

Boston, Massachusetts and Bonn, Germany

ABSTRACT

F¹⁸, 112 minute half-life positron-emitter was studied as a possible agent for brain tumor localization. Tissue studies in mice bearing subcutaneously transplanted tumors indicated that labeled potassium tetrafluoroborate showed good preferential uptake in tumor compared to brain with no excessive concentration in other organs. F¹⁸ labeled sodium fluoride gave very high concentrations in bone and is not suitable as a brain scanning agent. Tissue studies in cats with the fluoroborate ion confirm that there is no appreciable preferential tissue uptake. Blood studies in humans showed a suitable fall-off of the level of activity using the fluoroborate ion and a preliminary study of a small number of patients scanned with fluoroborate and other isotopic agents indicate that the former appears to be a suitable compound for brain tumor localization and merits further study.

FOOTNOTES

¹ This work was supported in part by grants from the U.S. Atomic Energy Commission [AT (30-1) 1242] the U.S.P.H.S. [C-3174], and the John A. Hartford Foundation.

² German Research Council Fellow, Present Address: Neurochirurgische Universitäts Klinik Bonn, Germany.

³ Massachusetts General Hospital, Boston, Massachusetts.