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The Metabolism of Ortho-I¹³¹ Iodobenzoic Acid. I. Its Use As a Possible Liver Function Test^1,2

Los Angeles, California and Punjab, India

ABSTRACT

The characterization and quantitation of the excretion of the metabolites of ortho-I¹³¹ iodobenzoic acid may possibly serve as a basis for the development of a new diagnostic test for liver function.

Methods for the preparation and determination of purity of the test agent, the performance of the test and the quantitation are described.

The conjugation and excretion were too slow to permit measurement of the removal from the blood by external monitoring over the side of the head. Similarly it was not possible to perform the customary renographic study in situ over the kidneys.

Results of the test in 8 controls, 11 patients with clinical diagnoses of liver cirrhosis and 2 patients with diagnoses of hepatitis indicate qualitative and quantitative differences in the excretion of total radioactivity, unchanged OI*BA, OI*HA, OI*BG and other metabolites.

Methods of analysis were devised which indicated several radioactive metabolites not reported heretofore. These may indicate enzyme systems which have some significance in pathological states.

Our studies indicate that cirrhotics and hepatitics produce more OI*HA and OI*BG than the controls do in all time periods tested.

These studies indicate that the major pathway for the detoxication of OI*BA is the formation of iodobenzoyl glucuronide and not iodohippuric acid.

FOOTNOTES

¹ From Radioisotope Research, Veterans Administration Center, Los Angeles, California 90073, and Departments of Radiology and Medicine, UCLA Center for the Health Sciences, Los Angeles, California 90024.

² This investigation supported in part by Public Health Service Research Grant AM-06636-02 from the National Institutes of Arthritis and Metabolic Diseases.

³ Present address: V. Langar Chhanni, P. O. Kesri, Dist. Ambala, Punjab, India.