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Volume Changes of Dialysate During Peritoneal Lavage As Determined by Means of Radioactive Isotopes¹

Cairo, U.A.R.

ABSTRACT

Changes in volume of dialyzing fluid with different dextrose content were estimated during peritoneal lavage in dogs by means of radio-iodinated human serum albumin and radioactive colloidal gold.

The volume of dialysate increased throughout the period of lavage. This change in volume was a biphasic exponential function of time; starting with a rapid component and ending with a slower phase. The rate of change as well as the final volume of dialysate were directly related to the dextrose concentration in the irrigating fluid.

For volume determination, radiogold proved to be better than radio-iodinated human serum albumin since its leakage into the blood was less together with its shorter half life; thus being more accurate and safer for clinical purposes.

FOOTNOTES

¹ This work was accepted for discussion in the symposium "Treatment of Uraemia" during The Second International Congress of Nephrology, Prague, Czechoslovakia, 1963.

² Medical Unit and Division of Nuclear Medicine, Faculty of Medicine, Cairo University Medical Unit, Atomic Energy Establishment, U.A.R.

³ Medical Unit, Faculty of Medicine, Cairo University.

⁴ Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University.